Stem Cells Knee

The problems of obesity on joint healing

A new study from Ohio State University tries to explain why obesity causes chronic pain. In this research the goal was to evaluate the degree to which dietary intake of foods with anti-inflammatory effects mediates the relationship of body fat to body pain.

The researchers went in a studied Ninety-eight community-residing healthy adults, the majority women with an average age of 43.

They examined:

  • home environment,
  • food-related behaviors,
  • health, and
  • obesity levels.

The participants were measured for body mass index and completed a 24-hour food recall interview and self-report measures of bodily pain and psychological distress. The quality of dietary food intake was also rated using the Healthy Eating Index-2010.

The conclusion of the study presented simple data indicating that dietary intake of foods with anti-inflammatory effects helps control body pain in obese individuals.1

This research was not the first to confirm such a connection.

Obesity is more than weight load – it causes inflammation

Doctors at the University of Calgary, in examining obese laboratory animals found that not only does obesity cause osteoarthritis because of weight load, but it also causes osteoarthritis in a “non-mechanical” way – in other words by inflammation without wear and tear. The inflammation attacking the joints of the animals was caused by a high fat/high sugar diet.2

This type of research is helping doctors get away from the excessive weight load model of thinking, although weight load does cause obvious problems, and helps them look at the inflammation problems.

This was confirmed by French researchers who suggest that the rising prevalence of hand osteoarthritis is from obesity and since the hand does not bear weight, this suggests that the role of systemic inflammatory mediators in fat cells cause inflammation signaling to be sent out and attack joints.3

A new study paints a grim but accurate picture of the effects of obesity on aging patients. In a group of patients who were mostly females average age 51, obesity was linked to mental distress, poor sleep quality and poor physical fitness. This lead to a condition of WSP – WideSpread musculoskeletal Pain.4

Simply: obesity + mental distress + poor sleep = Pain.  To effectively heal, these issues need to be addressed.

Knee replacement does not fix all these problems

Many patients are under the assumption that the quickest way to attack their obesity problem is to get a joint replacement. The thinking is that is they eliminate their knee pain they will be able to exercise and lose weight. Surgeons are being told to tell patients that is not true for many obese patients.

August 2016 Journal of Rheumatology:

  • Analyses showed that increasing BMI (Body Mass Index – Obesity) and anxiety levels and decreasing levels of positive social interactions were associated with increased patient costs (the need for continued care) following total knee replacement. The greater the obesity the greater the patient need for care (cost) following the knee replacement.5

Doctors in the United Kingdom had this to say in the July 2016 edition of  Maturitis

  • There is a proven association between obesity and knee osteoarthritis, and obesity is suggested to be the main modifiable risk factor.
  • Obese patients are more likely to require total knee replacement
  • It is unclear whether total knee replacement facilitates weight reduction
  • Surgery in obese patients is more technically challenging. This is reflected in the evidence, which suggests higher rates of short- to medium-term complications following total knee replacement , including wound infection and medical complications, resulting in longer hospital stay, and potentially higher rates of malalignment, dislocation, and early revision.6

In another study, doctors were much more critical of putting implants into obese patients:

High patient weight is a risk factor for mechanical implant failure and some manufacturers list obesity as a contraindication for implant use. Doctors in the United Kingdom were amazed to find out that:

  • A total of 10,745 patients in a two year period 2012-2013 received knee or hip implants against manufacturer recommendations.
  • 16% of all obese patients) received implants against manufacturer recommendations.7

The simply summary to all the research listed above is this:

Weight reduction strategies could potentially reduce the need for knee replacement surgery by 31% among patients with knee osteoarthritis.8

1 Emery CF, Olson KL, Bodine A, Lee V, Habash DL. Dietary intake mediates the relationship of body fat to pain. Pain. 2017 Feb;158(2):273-277. [Pubmed]

2. Collins KH, Reimer RA, Seerattan RA, Leonard TR, Herzog W. Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats. Osteoarthritis Cartilage. 2015 Feb 3. pii: S1063-4584(15)00028-X. doi: 10.1016/j.joca.2015.01.015. [Pubmed]

3. Berenbaum F, Eymard F, Houard X. Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol. 2013 Jan;25(1):114-8.[Pubmed]

4 Magnusson K, Hagen KB, Natvig B. Individual and joint effects of risk factors for onset widespread pain and obesity – a population-based prospective cohort study. Eur J Pain. 2016 Aug;20(7):1102-10. doi: 10.1002/ejp.834.[Pubmed]

5. Wu CL, Diekman BO, Jain D, Guilak F. Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fad pad: the effects of free fatty acids. International Journal of Obesity advance online publication, 20 November 2012; doi:10.1038/ijo.2012.171. [Pubmed]

Waimann CA, Fernandez-Mazarambroz RJ, Cantor SB, et al. Effect of Body Mass Index and Psychosocial Traits on Total Knee Replacement Costs in Patients with Osteoarthritis. J Rheumatol. 2016 Aug;43(8):1600-6. doi: 10.3899/jrheum.151301. [Journal Citation]

7. Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas. 2016 Jul;89:22-8. doi: 10.1016/j.maturitas.2016.04.006. Epub 2016 Apr 11. Review. [Pubmed]

8. Craik JD, Bircher MD, Rickman M. Hip and knee arthroplasty implants contraindicated in obesity. Ann R Coll Surg Engl. 2016 May;98(5):295-9. [Pubmed]

9. Leyland KM, Judge A, Javaid MK, Diez-Perez A, Carr A, Cooper C, Arden NK, Prieto-Alhambra D. Obesity and the Relative Risk of Knee Replacement Surgery in Patients With Knee Osteoarthritis: A Prospective Cohort Study. Arthritis Rheumatol. 2016 Apr;68(4):817-25. [Pubmed]




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